Sitagliptin Phosphate Monohydrate

Sitagliptin phosphate is a dipeptidyl peptidase-4 (DPP4) inhibitor developed by Merck. In October 2006, Sitagliptin phosphate Januvia was approved by FDA as the first DPP4 inhibitor for the treatment of type ⅱ diabetes mellitus. The characteristics of this drug are that it can stimulate insulin secretion while reducing hunger without causing weight gain. Hypoglycemia and edema will not occur, and it is suitable for diabetic patients with poor blood glucose control and frequent hypoglycemia.

key word:

hypoglycemia treatment stimulate

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API

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The company integrates multiple resources and strives to build a large health industry finance platform company integrating pharmaceutical, intelligent medical, bio pharmaceutical R&D, industrial production and sales.

The chemical reactions involved in the existing products include Foucault reaction, nitration reaction, sulfonation reaction, hydrogenation reaction, fluorination reaction, chlorination reaction, bromination reaction, diazotization reaction, format reaction, etc.

Blockbuster drug for type 2 diabetes

It is a dipeptidyl peptidase-4 (DPP4) inhibitor developed by Merck. In October 2006, Sitagliptin phosphate Januvia was approved by FDA as the first DPP4 inhibitor for the treatment of type ⅱ diabetes mellitus. The characteristics of this drug are that it can stimulate insulin secretion while reducing hunger without causing weight gain. Hypoglycemia and edema will not occur, and it is suitable for diabetic patients with poor blood glucose control and frequent hypoglycemia. By inhibiting the activity of this enzyme, the drug can relatively increase the levels of naturally occurring incretin, including glucagon-like peptide-1 and glucose-dependent insulin-stimulating peptide, thereby triggering the clinical effect of increasing insulin production in the pancreas and stopping glucose production in the liver, ultimately lowering blood glucose concentration. The DRUG HAS A PROMISING MARKET, WITH SALES OF sitaglipTIN PHOSPHATE REACHING $185 MILLION IN THE THIRD quarter OF 2007 alone. Peak sales of sitagliptin are forecast to reach $1 billion by 2010. $3.306 billion in 2020, combined with metformin in 2020 sales of $1.971 billion.

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Sitagliptin Phosphate Monohydrate

Sitagliptin phosphate is a dipeptidyl peptidase-4 (DPP4) inhibitor developed by Merck. In October 2006, Sitagliptin phosphate Januvia was approved by FDA as the first DPP4 inhibitor for the treatment of type ⅱ diabetes mellitus. The characteristics of this drug are that it can stimulate insulin secretion while reducing hunger without causing weight gain. Hypoglycemia and edema will not occur, and it is suitable for diabetic patients with poor blood glucose control and frequent hypoglycemia.

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